Treatment Schedule for Carcinoma In situ
Investigator* Indications Induction Maintenance Dose (mg) Route
Guinan (1883) CIS Prophylaxis Weekly x 6 Monthly x 12 50 Intravesical
Lamm (1414) CIS Prophylaxis Invasive Diagnosis Weekly x 6 At 8, 10, 12 weeks; 6 months; every 6 months x 4 years 0.5 & 50 mg Intravesical
Khanna (2951) Low Risk High Risk/CIS Weekly x 6 Monthly x 12, Every 3 months x 8 Every 6 months x 4 50 Intravesical
Brosman (1111) CIS Existing Tumor Prophylaxis Weekly to CR Every 2 weeks x 3 Months Monthly x 2 years 50 Intravesical
De Kernion (1571) CIS Existing Tumor Prophylaxis Weekly x 8 Monthly x 12 50 Intravesical
Williams (2427) CIS Prophylaxis Weekly x 6 Monthly x 12 50 Intravesical
*Investigational New Drug Application. Study numbers in parentheses.
Table 2: TICE BCG Series: Summary of Study Features