| Treatment Schedule for Carcinoma In situ |
| Investigator* |
Indications |
Induction |
Maintenance |
Dose (mg) |
Route |
| Guinan (1883) |
CIS
Prophylaxis |
Weekly x 6 |
Monthly x 12 |
50 |
Intravesical |
| Lamm (1414) |
CIS
Prophylaxis
Invasive Diagnosis |
Weekly x 6 |
At 8, 10, 12 weeks;
6 months; every 6
months x 4 years |
0.5 & 50 mg |
Intravesical |
| Khanna (2951) |
Low Risk
High Risk/CIS |
Weekly x 6 |
Monthly x 12,
Every 3 months x 8
Every 6 months x 4 |
50 |
Intravesical |
| Brosman (1111) |
CIS
Existing Tumor
Prophylaxis |
Weekly to CR |
Every 2 weeks x 3
Months
Monthly x 2 years |
50 |
Intravesical |
| De Kernion (1571) |
CIS
Existing Tumor
Prophylaxis |
Weekly x 8 |
Monthly x 12 |
50 |
Intravesical |
| Williams (2427) |
CIS
Prophylaxis |
Weekly x 6 |
Monthly x 12 |
50 |
Intravesical |
| *Investigational New Drug Application. Study numbers in parentheses. |
