Figure 1: Impact of SNPs rs12979860, rs4803217 and ss469415590 on the outcome of PEG- IFN/RBV treatment in HIV-1/HCV coinfected individuals. (A) Schematic representing the location of IFNL1-4 on chromosome 19. SNPs rs12979860 and ss469415590 are located upstream of IFNL3 whereas SNP rs4803217 is harbored in the 3’ UTR of IFNL3. (B) Table showing the race, sex, treatment response as well as rs12979860, rs4803217 and ss469415590 genotypes (determined using custom designed TaqMan qPCR based allelic discrimination assay, Life Technologies) in a cohort of HIV-1/HCV co-infected individuals utilized in the study. (C) Bar graph indicating the percentage of sustained virological responders in individuals carrying the given rs12979860 genotype (CC/CT/ TT). (D) Bar graph indicating the percentage of responders in individuals carrying the given rs4803217 genotype (GG/GT/TT). (E) Bar graph indicating the percentage of responders in individuals carrying the given ss469415590 genotype (TT/ΔGT/ ΔGΔG).