Figure 2: NoV GII-4-specific mucosal antibody responses in BALB/c mice. Mice were immunized twice with a NoV vaccine candidate containing 10 μg GII-4 VLPs. Intestinal IgG (A) and IgA (B) antibodies were analyzed from 10% fecal suspensions of IM and IN immunized mice (solid lines) or the control mice (dashed lines). Fecal samples of five mice/experimental group were pooled for analysis. Shown are mean ODs with the standard errors of the mean (SEM) of two independent experiments.