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Table 2: Monocyte subset functional phenotypes. Classical CD16-negative and CD16-positive non-classical monocytes can be classified according to their functional phenotype of scavenger receptor (CD163), cytokine expression, chemokine responsiveness, antigen presentation capacity (HLA-DR) and arginine metabolism (iNOS or Arg I). The combination of such phenotypes defines monocyte function as proinflammatory, CMI-inducing or tissue reparative, induction of humoral immunity. One point to be noted is that the classical and non-classical subsets express iNOS whereas the intermediate monocyte subset expresses arginase. Refer to macrophage table 1 earlier. This table has been adapted from [91,93,94,96,98,101,103,104]. |