p-STAT Control Group Treated Group +/-Δ% 1A No additions, 30’ rhIL-6+sIL-6R 0ns 1A No additions, 30’ rhIL-6 +22.3ns 1B No additions, 30’ rhIL-6+sIL-6R +73.3† 1B No additions, 30’ rhIL-6 +10.7ns 1B rhIL-6, 30’ rhIL-6+Janex-1 -27.7†† 1B DMSO, 30’ rhIL-6+Janex-1 -15.7ns 1B rhIL-6, 30’ rhIL-6+sIL-6R +56.6† †p<0.0001 by Chi-square analysis; ††p<0.05 by Chi-square analysis; nsnot significant by Chi-square analysis

Table 2: The Δ% change (+/-) in p-STAT1A and p-STAT1B after treatment of T/C28a2 chondrocytes with rhIL-6, rhIL-6+Janex-1 or rhIL-6+sIL-6R. The Δ% change (+/-) between the control group and treatment group was calculated from the bar graphs generated by Metamorph® software of the p-STAT1 western blot shown in Figure 3.