Figure 6: Effect of biochemical inhibitors on PC-3 High Invasive prostate cancer cell invasion activity and CCL2 levels in the co-culture withU-937 cells. (A) Prostate cancer cell invasion induced by co-culture with U-937 cells was inhibited with addition of Bay11-7082, Lactacystinand RS102895, but not with gefitinib. (B) CCL2 levels in co-culture supernatants were significantly reduced with Bay11-7082 or Lactacystintreatments, but not with RS102895 or gefitinib inhibitors. The data shown is expressed as the mean ± SD of three independent experiments.*P<0.05, **P<0.01, ***P<0.001, PC-3 High Invasive/U-937 versus with inhibitor or PC-3 High Invasive alone.