Children T1DM Parent/ Relative T2DM Parent/Relative Relation Shared haplotypes 1 DRB1*03:01:01:01, DRB1*04:01:01 DQB1*02:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Father DRB1*04:01:01- DQB1*03:02:01 2 DRB1*03:01:01:01, DRB1*04:01:01 DQB1*02:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Father DRB1*04:01:01- DQB1*03:02:01 3 DRB1*04:01:01, DRB1*11:01:01 DQB1*03:02:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Father DRB1*04:01:01- DQB1*03:02:01 4 DRB1*03:01:01:01, DRB1*04:01:01 DQB1*02:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Father DRB1*04:01:01- DQB1*03:02:01 5 DRB1*04:01:01, DRB1*11:01:01 DQB1*03:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Father DRB1*04:01:01- DQB1*03:02:01 6 DRB1*03:01:01:01, DRB1*04:01:01 DQB1*02:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*11:01:01 DQB1*03:01:01, DQB1*03:02:01 Mother DRB1*04:01:01- DQB1*03:02:01 7 DRB1*03:01:01:01, DRB1*04:01:01 DQB1*02:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Father DRB1*04:01:01- DQB1*03:02:01 8 DRB1*03:01:01:01, DRB1*04:01:01 DQB1*02:01:01,  DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Mother DRB1*04:01:01- DQB1*03:02:01 9 DRB1*04:01:01,  DRB1*04:01:01 DQB1*02:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*05:01:01 Mother DRB1*04:01:01- DQB1*03:02:01 10 DRB1*04:01:01, DRB1*05:01:01 DQB1*03:02:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Father DRB1*04:01:01- DQB1*03:02:01 11 DRB1*03:01:01:01, DRB1*04:01:01 DQB1*02:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Mother DRB1*04:01:01- DQB1*03:02:01 12 DRB1*16:01:01,  DRB1*04:01:01 DQB1*06:01:01,DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Grandfather DRB1*04:01:01- DQB1*03:02:01 13 DRB1*03:01:01:01, DRB1*04:01:01 DQB1*02:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Mother DRB1*04:01:01- DQB1*03:02:01 14 DRB1*04:01:01, DRB1*07:01:01 DQB1*03:02:01, DQB1*03:03:02 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Mother DRB1*04:01:01- DQB1*03:02:01 15 DRB1*15:01:01:01 DRB1*04:01:01 DQB1*06:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Grandfather DRB1*04:01:01- DQB1*03:02:01 16 DRB1*03:01:01:01, DRB1*04:01:01 DQB1*02:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Grandmother DRB1*04:01:01- DQB1*03:02:01 17 DRB1*03:01:01:01, DRB1*04:01:01 DQB1*02:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Mother DRB1*04:01:01- DQB1*03:02:01 18 DRB1*03:01:01:01, DRB1*04:01:01 DQB1*02:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Mother DRB1*04:01:01- DQB1*03:02:01 19 DRB1*03:01:01:01, DRB1*04:01:01 DQB1*02:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Mother DRB1*04:01:01- DQB1*03:02:01 20 DRB1*04:01:01, DRB1*10:01:01 DQB1*05:01:01, DQB1*03:02:01 DRB1*04:01:01, DRB1*04:01:01 DQB1*03:02:01, DQB1*03:02:01 Mother DRB1*04:01:01- DQB1*03:02:01 21 DRB1*03:01:01:01, DRB*13:01:01:01 DQB1*06:01:01, DQB1*02:01:01 DRB1*03:01:01:01, DRB1*10:01:01 DQB1*05:01:01, DQB1*02:01:01 Mother DRB1*03:01:01:01- DQB1*02:01:01 22 DRB1*03:01:01:01, DRB1*03:01:01:01 DQB1*02:01:01, DQB1*02:01:01 DRB1*03:01:01:01, DRB1*16:01:01 DQB1*02:01:01, DQB1*05:01:01 Grandfather DRB1*03:01:01:01- DQB1*02:01:01 23 DRB1*03:01:01:01, DRB1*07:01:01:01 DQB1*02:01:01, DQB1*03:01:01 DRB1*07:01:01:01, RB1*07:01:01:01 DQB1*03:01:01, DQB1*03:01:01 Father DRB1*07:01:01:01- DQB1*03:01:01 24 DRB1*03:01:01:01, DRB1*07:01:01:01 DQB1*02:01:01, DQB1*02:01:01 DRB1*15:01:01:01, DRB1*07:01:01:01 DQB1*06:01:01, DQB1*02:01:01 Father DRB1*07:01:01:01- DQB1*02:01:01

Table 1: Distribution of shared HLA-DRB1 and DQB1 alleles and their haplotype combinations in 24 separate Bahraini families with T1DM and T2DM.