Figure 2: Polarization of innate immune cells toward a pro angiogenic phenotype and function during NSCLC tumor growth and progression. The tumor mass fate, their invasive capacity, dissemination and clinical outcome are strictly dependent of the interactions with innate polarized pro-tumor and pro-angiogenic innate cells. Among these cells, M2/TAM, N2/TAN, regDC, MDSC, TINK and CAF are main actors playing key roles in shaping the TUMIC with capacities that lead to evasion from immune recognition and destruction, tumor-promoting inflammation and angiogenesis.