| Protein |
Functions |
| MIF |
Immune factor; binds to CD74 to trigger acute immune response |
| CTSC |
Peptidase; central coordinator for activation of many serine proteases in immune/inflammatory cells |
| CTSS |
Peptidase; involved in antigen presentation on MHC class II molecules and function as an elastase in alveolar macrophages |
| ANXA2 |
Phospholipid-binding protein; involved in cellular processes such as cell motility, ion channel formation, and cell matrix interactions |
| FLNA |
Actin-binding protein; regulates reorganization of the actin cytoskeleton by interacting with integrins |
| LRG1 |
Involved in signal transduction and granulocyte differentiation |
| Lum |
Keratan sulfate proteoglycan; regulates collagen fibril organization, epithelial cell migration, and tissue repair |
| ITIH4 |
IαI protein; forms (SHAP)-HA complex; present at high concentration in rheumatoid arthritic synovial fluid |
| MANF |
Secreted protein; protects nigral dopaminergic neurons and cardiac myocytes |
| ACR |
Protease; involved in lysis of the zona pellucida, thus facilitating penetration of the sperm through glycoprotein layers of the ovum |
| SIAE |
Acetylesterase; interferes with Siglec binding on immune cells |
| Based on data reported in [3].
MIF:Macrophage Migration Inhibitory Factor; CTSC:Cathepsin C; CTSS:Cathepsin S; ANXA2:Annexin A2; FLNA:Filamin A alpha; LRG1:Leucine-Rich Alpha-2-Glycoprotein 1; Lum:Lumican; ITIH4:Inter-alpha-Trypsin Inhibitor Heavy Chain 4; MANF:Mesencephalic Astrocyte-derived Neurotrophic Factor; ACR:Acrosin; SIAE:Sialic Acid Acetylesterase |
