miRNA Expression1 Role in PCa Mediated Function Validated Target Genes Castration Resistance2 Biomarker Application References
miR-21 Upregulated Oncogene Viability, invasion, apoptosis, migration MARCKS, TPM1, PDCD4 Yes Diagnostic, prognostic, predictive [38,53,55,57,115]
miR-221~222 Upregulated Oncogene Proliferation CDKN1B, HECTD2, IRF2, RAB1A, SOCS3 Yes Diagnostic, prognostic [55,65-68]
miR-125 Upregulated Oncogene Apoptosis, proliferation BAK1, EIF4EBP1, TP53, PUMA, ARF Yes   [69,72-77]
miR-32 Upregulated Oncogene Apoptosis BTG2 Yes   [40]
miR-148a Upregulated Oncogene Proliferation PIK3IP1     [40]
miR-616 Upregulated Oncogene Proliferation TFPI-2 Yes   [123]
miR-34 Downregulated Tumor suppressor Proliferation, apoptosis, metastasis, EMT3 Cyclin-E2, CDK6, E2F5, E2F1, E2F3, BCL2, CD44   Diagnostic [83,85-89,95]
miR-15~16 Downregulated Tumor suppressor Proliferation, invasion, metastasis CDK1, CDK2, BCL2, CCND1, WNT3A   Diagnostic [46,93-95,115]
miR-141/200 Downregulated Tumor suppressor EMT3 ZEB1, ZEB2, SNAIL2   Diagnostic, prognostic [53,97-99,102-106]
Let-7 Downregulated Tumor suppressor Proliferation, clonogenicity MYC Yes Diagnostic, prognostic [109,116-118]
miR-101 Downregulated Tumor suppressor Proliferation, invasion, metastasis EZH2     [119]
miR-126 Downregulated Tumor suppressor Viability, invasion, migration Prostein     [120]
miR-146a Downregulated Tumor suppressor Proliferation, invasion, metastasis ROCK1 Yes   [121]
miR-330 Downregulated Tumor suppressor Proliferation, apoptosis E2F1     [122]
1PCa cohort vs Benign cohort
2Involved in the development of Castration Resistant Prostate Cancer (CRPC)
3EMT: epithelial mesenchymal transition
Table 1: Summary of studies on deregulated miRNAs in PCa.