Figure 3: Link between M1/M2 polarization and intra-macrophage redox state. Left: low GSH/GSSG in macrophages induced by pathogens correlates with defective antigen processing and low IL-12 production leading to switch from the typical Th1 cytokine profile towards Th2 response patterns. Right: high GSH/GSSG in macrophages induced by synthetic molecules restores antigen processing and high IL-12 production favoring Th1 response patterns.