Figure 4: CRP binding to amyloid precursor protein. (A) Binding of CRP to Aβ or Sm/RNP in the absence or presence of 2 mM Ca2+ was assessed by ELISA. (B, C) Binding of biotinylated CRP to HSA or AP-HSA in the absence (B) or presence (C) of 2 mM Ca2+ was determined by ELISA. Error bars are means ± SEM of duplicate wells. Similar results were obtained from at least three independent experiments (*p<0.05, **p<0.005 and ***p<0.0005 compared with HSA).