| Immunological assay |
Main results |
Reference |
Plasma cytokines
(ELISA) |
Higher IL-6 level in TB-IRIS patients compared to non-IRIS individuals |
[37] |
Cell phenotyping
(WB, flow cytometry) |
Increased TNF, IL-6, IL-1b, IL-10, RANTES, and MCP-1 levels and high frequency of activated CD4+ T-cells in TB-IRIS patients |
[18] |
Cell phenotyping
(WB, flow cytometry) |
Similar frequencies of activated CD4+ and CD8+ T-cells and CD4+ Treg cells among TB-IRIS and non-IRIS individuals |
[20] |
Cell phenotyping
(PBMC, flow cytometry) |
Higher frequency of activated CD4+ T-cells and CD4+ Treg cells (CD25+CD127low and CTLA-4+) in TB-IRIS patients compared to healthy individuals. |
[30] |
Cell phenotyping
(WB, flow cytometry) |
Lower frequency of TCRgd and Vd2+ T cells expressing CD94/NKG2 and CD158ah,b in TB-IRIS patients compared to non-IRIS individuals. |
[22] |
Plasma cytokines
(flow cytometry and ELISA) |
Increased IL-18 and CXCL10 levels and decreased CCL2 in TB-IRIS patients compared to non-IRIS individuals. |
[19] |
Plasma cytokines
(ELISA) |
At baseline, higher TNF and IL-10 levels in TB-IRIS patient compared to non-IRIS individuals. Higher IFN-γ levels in TB-IRIS patients after HAART compared to baseline. |
[34] |
Plasma cytokines
(Luminex technology) |
Higher frequency of activated NK cell and C-reactive protein, IL-8, EGF, and HGF levels in TB-IRIS patients compared to non-IRIS patients. |
[24] |
Cell phenotyping
(whole blood, flow cytometry) |
Higher expression of TLR2 on mDC and monocytes of TB-IRIS patients compared to non-IRIS individuals |
[35] |
Cytokines
(RT-PCR) |
Increase quantity of IL-2, IL-5, IL10, IL-12p40, IL-13, IL-15, IL-17A, TGF-b, and TNF transcripts in TB-IRIS patients compared to non-IRIS individuals |
[23] |
Cell phenotyping
(WB, flow cytometry) |
Expansion of central memory CD4+ T-cells following HAART. |
[25] |
Cytokines levels
(CSF, flow cytometry) |
Higher TNF, IFN-g and IL-6 levels in TB-IRIS patients compared to non-IRIS individuals |
[27] |
