Cancer immunotherapy approaches using macrophages
Type Name Result
Cytokine/chemokine IFN-α and IFN-β Inhibits tumor progression
Induce apoptosis in cancer cells
Induce differentiation of monocytes to macrophages
CCR2 Prevents recruitment of monocytes/macrophages to the tumor site
Anti-MIF shRNA Depletes M2 macrophage population from tumor site
Inorganic molecules MENK Polarized macrophages from M2 to M1
Downregulates CD2016, arginase 1, and IL-10
Upregulates CD64, MHC-IL, TNF-α, and nitric oxide
Bisphosphonates Induce apoptosis in TAMs
Reduce the number of infiltrating TAMs to the tumor site
Impairs angiogenesis
Cationic polymers (PEI, polylysine, cationic dextran and cationic gelatin) Induces Th1 response
Induce proliferation of CD4+ cells
Induce upregulation of IL-12in macrophages
Vesicles Liposomes Deplete IL-1β producing cancer cells
Inhibits production of angiogenic factor (VEGF-A, IL-8, monocyte chemoattractant protein 1)
Table 1: Summary of cancer immunotherapy approaches.