| Subject characteristics |
Healthy controls |
LTBI individuals |
Untreated TB patients |
Treated TB patients |
| N |
12 |
28 |
17 |
5 |
| Median age (years) [range] |
26 [24-61] |
41 [22-58] |
32 [20-53] |
23 [20-52] |
| sex |
|
| female n (%) |
10 (83,3) |
19 (67,9) |
7 (41,2) |
3 (60) |
| male n (%) |
2 (16,7) |
9 (32,1) |
10 (58,8) |
2 (40) |
| Ethnic origin |
|
| Caucasian n (%) |
8 (66,7) |
17 (60,7) |
5 (29,4) |
2 (40) |
| North African n (%) |
4 (33,3) |
4 (14,3) |
3 (17,6) |
2 (40) |
| Sub Saharian n (%) |
0 (0) |
5 (17,9) |
7 (41,2) |
0 (0) |
| Hispanic n (%) |
0 (0) |
2 (7,1) |
2 (11,8) |
1 (20) |
| BCG status |
|
| Vaccinated >10y ago n (%) |
0 (0) |
18 (64,3) |
0 (0) |
1 (20) |
| Vaccinated date unknown n (%) |
0 (0) |
3 (10,7) |
2 (11,8) |
0 (0) |
| Unvaccinated n (%) |
12 (100) |
4 (14,3) |
7 (41,2) |
3 (60) |
| Unknown n (%) |
0 (0) |
3 (10,7) |
8 (47,1) |
1 (20) |
| TSTa [range] |
|
|
|
|
| Negative n (%) |
12 (100) |
0 (0) |
1 (5,9) |
0 (0) |
| Positive n (%) |
0 (0) |
28 (100) |
5 (29,4) |
2 (40) |
| Unknown n (%) |
0 (0) |
0 (0) |
11 (64,7) |
3 (60) |
| Detailed status |
|
| Recent LTBI n (%)b |
- |
5 (17,9) |
- |
- |
| Remote LTBI n (%)c |
- |
15 (53,6) |
- |
- |
| Unknown n (%) |
- |
8 (28,6) |
- |
- |
| Pulmonary TB n (%) |
- |
- |
10 (58,8) |
2 (40) |
| Disseminated TB n (%) |
- |
- |
7 (41,2) |
3 (60) |
| Treatment (days)[range] |
- |
|
|
90 [15-180] |
| Diagnosis |
|
| Culture positive n (%) |
- |
- |
13 (76,5) |
3 (60) |
| Culture negative n (%) |
- |
- |
4 (23,5) |
2 (40) |
| QFTd |
|
| Negative n (%) |
- |
18 (64,3) |
- |
- |
| Positive n (%) |
- |
10 (35,7) |
- |
- |
| aTST: tuberculin skin test; bRecent M. tuberculosis infections indicate infections<2years; cRemote M. tuberculosis infections indicate infections ≥ 2years; dQFT:
QuantiFERON-TB Gold in-tube assay |
|
