Lymphoproliferative
Figure 5: Patient with Post Transplant Lymphoproliferative Disease. A) Representative FACS plot of IFNγ production after BZLF-1 stimulation throughout follow up for CD4+ T cells (left panel) and CD8+ T cells (right panel). B) Graph showing viral load (EBV DNA in copies/ml; black line, left y-axis) and % IFNγ producing T cells (right y-axis, dark grey squares: BZLF-1 stimulated CD4+ T cells; grey triangles: BZLF-1 stimulated CD8+ T cells; light grey dashed line: EBNA-1 stimulated CD8+ T cells; dark grey dashed line: BZLF-1 stimulated CD4+ T cells) during follow up (months post SCT, x-axis). C) Graph showing the viral load (EBV DNA in copies/ml; black line, left y-axis) and the absolute number of T cells/μl blood ( right y-axis, dark grey circles, CD3+ T cells; dark grey squares, CD4+ T cells; light grey triangles, CD8+ T cells) during follow up (months post SCT, x-axis). D) Graph showing percentages of IFNγ producing T cells (y-axis) after restimulation with PMA/ionomycin following stimulation with BZLF-1 (CD4+ T cells, grey circles; CD8+ T cells, black squares) or EBNA-1 (CD4+ T cells, grey triangles; CD8+ T cells, black triangles) during follow up (months post SCT (x-axis).