| % Decrease in NKCC in CFS vs. Controls |
CFS Case Definition |
Number of Patients and Controls Studied |
Comments |
Reference |
| ↓ 64% - (median) p<0.001 |
1988 CDC |
CFS: 30
Healthy: 73 |
E:T ratio 1:1, K562=target |
[7] |
↓ NKCC (no values provided)
p<0.03 |
1988 CDC |
CFS: 5
NC:4 |
Age/sex matched, published as a letter,6 E:T ratios from 100:1 to 3:1, K562=target |
[25] |
| ↓ 72%-75% (mean) p<0.01 |
1988 CDC |
CFS: 10
Fatigue non-CFS: 24
Healthy Non-fatigued controls: 21 |
2 E:T ratios, 10:1 and 20:1, K562=target |
[26] |
| ↓ NKCC (no values provided) p<0.05 |
1988 CDC |
CFS: 20
Healthy: 50 |
4 E:T ratios 50:1 to 6.25:1, K562=target |
[27] |
| ↓68% (LU) |
1988 CDC |
CFS: 16
Healthy: 12 |
E:T ratios from 50:1 to 6.25:1, K562=target |
[28] |
| No↓ seen (no values provided) |
1988 CDC |
CFS: 21
NC: 21 |
Age/sex matched, E:T ratios not provided, K562=target |
[29] |
| No↓ seen at each of 5 E:T ratios |
1988 CDC |
CFS: 16
Healthy: 50 |
5 E:T ratios from 50:1 to 3:1, K562=target |
[30] |
| ↓63% (mean LU) |
1988 CDC |
CFS: 20
NC: 20 |
4 E:T ratios from 40:1 to 5:1, K562=target |
[31] |
| ↓63% (mean LU) p<0.05 |
1988 CDC |
CFS: 91a
NC: 30 |
Target cell = (HHV-6)- infected H9 cells, 4 E:T ratios 40:1 to 5:1 |
[24] |
| ↓62% (median LU) p<0.006 |
1988 and 1994 CDC |
CFS: 8
UFM: 12
NC: 8 |
Family members with CFS and unaffected family members (UFM), 4 E:T ratios 50:1 to 6:1, K562=target |
[32] |
| ↓42% (mean) p<0.003 |
1994 CDC |
CFS: 29
Healthy: 29 |
Series of 29 consecutive CFS patients; E:T ratio 1:1, K562=target |
[9] |
| ↓46% p<0.001 |
1994 CDC |
CFS: 30
Healthy sedentary controls: 19 |
E:T ratio 1:1, K562=target |
[34] |
| ↓57% (median) p<0.001 |
1994 CDC |
CFS: 176
Healthy: 230 |
E:T ratio 1:1, K562=target |
[12] |
NC: Normal Controls; LU: Lytic Units
aSubset of CFS patients meeting the CDC 1988 CD, but with lower levels of CD5, CD8, and CD11a mononuclear cell membrane receptors. |
