Figure 3: Nrf2-ARE activity is enhanced in cells polarized with IFN-γ. NR8383 cells (1 million/well) were treated with IFN-γ as above. Seventy-two hours later, protein expression of Nrf2 and its downstream effector GCLC were significantly increased in IFN-γ polarized cells as assessed by flow cytometry. Data presented as mean ± SEM, n=3. *p<0.05 compared with IL-4 treated cells. MFI=Mean fluorescence intensity.