Gene name Physiological function Co-regulated genes in B. mori Dorsal NF ΚB transcription factor BmToll, Spatzle BmRel NF ΚB transcription factor PPAE, Hsp70, Caspase Spatzle Cytokine that binds with Toll receptor to initiate the Toll signalling Dorsal, Caspase PPAE Enzyme that activates prophenol oxidase activity to initiate melanisation DDC, Chaperonin, Hsp70, BmRel, Caspase Caspase Apoptosis induction Notch, Spatzle, PPAE, BmRel

*Anitha et al. 2013

Table 3: Genes that showed pleiotropic regulation* of expression of different genes in the normal larvae of B. mori and deregulated after infestation with E. bombycis.