| |
|
Pre-operativeD0 |
Post-operativeD7 |
Δ-D0 |
P(Time effect) |
| Kynurenine (m mol/L) |
CRC |
1.7
[1.4; 2.1] |
2
[1.5; 2.6] |
0.3
[-0.2; 1] |
< 0.001 |
| |
Control |
1.25
[0.9; 1.78] |
1.5
[1.2; 2.42] |
0.35
[0.07; 0.9] |
0.002 |
| |
P (group effect) |
0.004 |
0.118 |
0.615 |
|
| Tryptophan (m mol/L) |
CRC |
31.4
[26; 38.2] |
34
[29.3; 42.4] |
2.1
[-4.8; 12.1] |
0.057 |
| |
Control |
31.8
[27.92; 41.5] |
34.6
[27; 38.55] |
1.25
[-7; 5.83] |
0.918 |
| |
P
(group effect) |
0.744 |
0.651 |
0.328 |
|
| Kyn/Trp |
CRC |
0.05
[0.04; 0.6] |
0.06
[0.04; 0.7] |
0.01
[-0.01; 0.02] |
0.131 |
| |
Control |
0.04
[0.03; 0.05] |
0.05
[0.04; 0.06] |
0.01
[0; 0.02] |
0.003 |
| |
P (group effect) |
<0.001 |
0.223 |
0.164 |
|
|
|
| group effect - Wilcoxon rank sum test / time effect Wilcoxon rank sum test for paired data |
Table 2: Serum tryptophan, kynurenine and the kynurenine-totryptophan ratio (kyn/ trp) in patients with CRC (CRC) and without
CRC (Control) at D0 and D7. Data are expressed as median [first quartile ; third quartile]. |
