Pre-operativeD0 Post-operativeD7 Δ-D0 P(Time effect)
Kynurenine (m mol/L) CRC 1.7
[1.4; 2.1]
2
[1.5; 2.6]
0.3
[-0.2; 1]
< 0.001
  Control 1.25
[0.9; 1.78]
1.5
[1.2; 2.42]
0.35
[0.07; 0.9]
0.002
  P (group effect) 0.004 0.118 0.615  
Tryptophan (m mol/L) CRC 31.4
[26; 38.2]
34
[29.3; 42.4]
2.1
[-4.8; 12.1]
0.057
  Control 31.8
[27.92; 41.5]
34.6
[27; 38.55]
1.25
[-7; 5.83]
0.918
  P
(group effect)
0.744 0.651 0.328  
Kyn/Trp CRC 0.05
[0.04; 0.6]
0.06
[0.04; 0.7]
0.01
[-0.01; 0.02]
0.131
  Control 0.04
[0.03; 0.05]
0.05
[0.04; 0.06]
0.01
[0; 0.02]
0.003
  P (group effect) <0.001 0.223 0.164  
group effect - Wilcoxon rank sum test / time effect Wilcoxon rank sum test for paired data
Table 2: Serum tryptophan, kynurenine and the kynurenine-totryptophan ratio (kyn/ trp) in patients with CRC (CRC) and without
CRC (Control) at D0 and D7. Data are expressed as median [first quartile ; third quartile].