Registered No. Intervention Start Year Patient Phase Sponsor Status NCT00004248 Doxorubicin and IL-2 1999 Patients with liver cancer that cannot be removed by surgery II Roswell Park Cancer Institute Completed NCT01522820 Vaccine therapy with or without Sirolimus 2012 Patients with NY-ESO-1 expressing solid tumors I Roswell Park Cancer Institute, National Cancer Institute Ongoing, but not recruiting NCT02562755 Vaccinia virus-based immunotherapy + SorafenibvsSorafenib alone 2015 Advanced HCC without prior systemic therapy III SillaJen, Inc. Not yet recruiting

Table 6: Clinical trials of combination therapy on hepatocellular carcinoma.