Receptor-Ligand Hydrogen Bond Interactions Hydrophobic Interactions Ligand Residues Receptor Residues Ligand Residues Receptor Residues Wild MEFV - PTPN12 Asp23, Ser68 Gln198, Arg737 Phe54, Ser67, Gly69 Leu194, Glu195, Gly196, Gly197, Ala736, Mutated MEFV - PTPN12 Gln9, Arg12, Asn49, Asp103, Asn113, Asp170 Gly4, Ser5, Gly7, Ala29, Gly30, Ile36, Leu37, Glu38, Glu40, Asp41, Trp43, Thr45, Phe54, Lys62, Leu63, Ser64, Gly65, Pro66, Ser67, Ser68, Gly69, Leu10, Ser38, Pro41, Arg42, Met53, Thr101, Asp102, Ala105, Ala106, Ser108, Ser109, Leu110, Gly111, Glu112, Lys114, Pro115, Thr326, Leu396, Ile397, Trp626, Leu770, Ile772

Table 1: Receptor (MEFV) and Ligand (PTPN12) residues involved in interactions.