Receptor-Ligand Hydrogen Bond Interactions Hydrophobic Interactions
Ligand Residues Receptor Residues Ligand Residues Receptor Residues
Wild MEFV - PTPN12 Asp23, Ser68 Gln198, Arg737 Phe54, Ser67, Gly69 Leu194, Glu195, Gly196, Gly197, Ala736,
Mutated MEFV -
PTPN12
Gln9, Arg12, Asn49, Asp103, Asn113, Asp170 Gly4, Ser5, Gly7, Ala29, Gly30, Ile36, Leu37, Glu38, Glu40, Asp41, Trp43, Thr45, Phe54, Lys62, Leu63, Ser64, Gly65, Pro66, Ser67, Ser68, Gly69, Leu10, Ser38, Pro41, Arg42, Met53, Thr101, Asp102, Ala105, Ala106, Ser108, Ser109, Leu110, Gly111, Glu112, Lys114, Pro115, Thr326, Leu396, Ile397, Trp626, Leu770, Ile772
Table 1: Receptor (MEFV) and Ligand (PTPN12) residues involved in interactions.