Figure 5: Effect of ZOSL in preventing Arthus reaction. It was seen that the footpad thickness came to normal after regular administration of ZOSL. (Values are mean thickness of footpad in mm measured by vernier caliper. The statistical significance was performed by the student T-test by using MedCalc software. Positive Control was compared with Experimental 1 and Experimental 2 where *P ≤ 0.05, $P ≤ 0.005, @P ≤ 0.0005, #P ≤ 0.05).