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Case 1 |
Case 2 |
Case 3 |
Case 4 |
Case 5 |
Female, 55 years old,
social assistant |
Male, 24 years old, law student and amateur actor |
67 year old, housewife |
Female, 42 years old, entrepreneur |
Female high school student, 18 years old |
| Symptomatology |
Progressive weight loss, daily episodes of diarrhea and cramps/abdominal pain (up to 30 bowel movements/day of semi-liquid stool;). |
Abdominal pain and frequent diarrheal bowel movements (three/four movements/day of semi-liquid feces without blood, often with the presence of discrete quantities of mucus) |
Diffuse cramps/abdominal pain associated with liquid normochromic stools in the absence of mucus and/or blood (about 10 bowel movements/day); hyporexia with a weight loss of about 15kg |
Frequent intestinal movements (2-3 discharges of stools a day, sometimes liquid and sometimes semi-liquid; gradual abdominal distension and flatulence |
Diarrhea, colicky abdominal pain in mesogastrium and lower quadrants of the abdomen, asthenia and laboratory findings of iron-deficiency anemia |
| Histological Findings |
Large bowel biopsy: H&E staining shows a lymphogranulocytic and plasmacellular nflammatory infiltration in the lamina propria, and increased number of intraepithelial T lymphocytes (IELs), |
Large bowel biopsy: H&E staining shows a moderate lymphogranulocytic and plasmacellular inflammatory infiltration in the lamina propri ; increase of the intraepithelial T lymphocytes (IELs), typical of lymphocytic colitis |
Immunohistochemical analysis of T lymphocytes in LC with anti-CD3 antibody (DAKO). Colonic mucosa showing increased IELs in a patient with lymphocytic colitis. |
Large bowel biopsy: H&E staining (on the left) shows a moderate lymphogranulocytic and plasmacellular inflammatory infiltration in the lamina propria. CD3 immunostaining (picture on the right) highlights the increase of the intraepithelial T lymphocytes (IELs). |
Large bowel biopsy: H&E staining (on the left) shows a moderate lymphogranulocytic and plasmacellular inflammatory infiltration in the lamina propria. CD3 immunostaining (picture on the right) highlights the increase of the intraepithelial T lymphocytes (IELs). Marked thickening of the sub-epithelial collagen band (arrowhead |
