Case 1 Case 2 Case 3 Case 4 Case 5
Female, 55 years old,
social assistant
Male, 24 years old, law student and amateur actor 67 year old, housewife Female, 42 years old, entrepreneur Female high school student, 18 years old
Symptomatology Progressive weight loss,  daily episodes of diarrhea and  cramps/abdominal pain (up to 30 bowel movements/day of semi-liquid stool;). Abdominal pain and frequent diarrheal bowel movements (three/four movements/day of semi-liquid feces without blood, often with the presence of discrete quantities of mucus) Diffuse cramps/abdominal pain associated with liquid normochromic stools in the absence of mucus and/or blood (about 10 bowel movements/day);  hyporexia with a weight loss of about 15kg Frequent intestinal movements (2-3 discharges of stools a day, sometimes liquid and sometimes semi-liquid; gradual abdominal distension and flatulence Diarrhea, colicky abdominal pain in mesogastrium and lower quadrants of the abdomen, asthenia and laboratory findings of iron-deficiency anemia
Histological Findings Large bowel biopsy: H&E staining shows a lymphogranulocytic and plasmacellular nflammatory infiltration in the lamina propria, and  increased number of intraepithelial T lymphocytes (IELs), Large bowel biopsy: H&E staining shows a moderate lymphogranulocytic and plasmacellular inflammatory infiltration in the lamina propri ;  increase of the intraepithelial T lymphocytes (IELs), typical of lymphocytic colitis Immunohistochemical analysis of T lymphocytes in LC with anti-CD3 antibody (DAKO). Colonic mucosa showing increased IELs in a patient with lymphocytic colitis. Large bowel biopsy: H&E staining (on the left) shows a moderate lymphogranulocytic and plasmacellular inflammatory infiltration in the lamina propria. CD3 immunostaining (picture on the right) highlights the increase of the intraepithelial T lymphocytes (IELs). Large bowel biopsy: H&E staining (on the left) shows a moderate lymphogranulocytic and plasmacellular inflammatory infiltration in the lamina propria. CD3 immunostaining (picture on the right) highlights the increase of the intraepithelial T lymphocytes (IELs). Marked thickening of the sub-epithelial collagen band (arrowhead
Table 1: Case series.