extravasation
Figure 3: Bladder weight and Evan’s Blue extravasation in rats at the end of the dosing regimen. A. Bladder weights at the end of treatment. Untreated rats were not entered into the dosing regimen and sacrificed with no treatments. At the end of the experiment bladders were harvested, cleaned of all fat and weighed. Bars represent the mean ± SEM. n=4 for untreated, vehicle-treated LPSinjected and Gly-treated LPS-injected groups. n=5 for vehicletreated saline-injected and glyburide-treated saline-injected groups. Asterisks demark significant differences (P<0.05) between the indicated bars. B. Evan’s blue extravasation into the bladder. Untreated rats were not entered into the dosing regimen and sacrificed with no treatments other than Evan’s Blue injection. At the end of the experiment bladders were harvested and dye extracted and quantitated as described in the Methods section. Bars represent the mean ± SEM. n=8 for untreated, 5 for vehicle-treated saline-injected and glyburide-treated saline-injected groups. n=4 for vehicle-treated LPS-injected and Gly-treated LPS-injected groups. Asterisks demark significant differences (P<0.05) between the indicated bars.