Figure 1: Schematic presentation of the multiple gut-brain, joint, bone, endocrine, liver, kidney, heart, lung and skin axes. Centered by the intestinal ecosystem with nutrients, microbiota/dysbiota and their PTMPs capacity and the leaky gut, multiple arrows are directed to the corresponding organs, detailing some examples of corresponding ADs. IBD: Inflammatory Bowel Diseases; CVD: Cardiovascular Diseases; Met Syn: Metabolic Syndrome; MS: Multiple Sclerosis; PD: Parkinson’s Disease; RA: Rheumatoid Arthritis; SpA: Spondyloarthropathy; PA: Psoriatic Arthritis; CKD: Chronic Kidney Diseases; IDDM: Insulin Dependent Diabetes Mellitus; CF: Cystic Fibrosis; COPD: Chronic Obstructive Pulmonary Disease; NALFD: Non-Alcoholic Fatty Liver Disease; PTMP: Post Translational Modification of Proteins; Ads: Autoimmune Diseases.