GENE/SNP

Genotype/

CD

UC

IBD

Allele

P valuea (Pcorr)b

OR (95 % CI)

P valuea (Pcorr)b

OR (95 % CI)

P valuea (Pcorr)b

OR (95 % CI)

PTPN11

 

 

 

 

 

 

 

Rs11066320

AA

0.69

 

0.6

 

0.56

 
 

AG

0.022 (0.066)

2.48 (1.17; 5.25)

0.09

1.67(0.89;3.15)

0.019 (0.057)

1.93(1.11; 3.36)

 

GG

0.018 (0.054)

0.4 (0.19; 0.82)

0.06

0.58 (0.32; 1.06)

0.011 (0.033)

0.51 (0.3; 0.86)

 

A

0.034 (0.068)

1.90(1.08; 3.33)

0.079

1.50(0.93; 2.42)

0.02 (0.04)

1.64 (1.08; 2.49)

 

G

           

Rs12423190

CC

0.48

 

0.35

 

0.24

 
 

CT

               0.16

 

0.54

 

0.23

 
 

TT

0.12

 

0.42

 

0.15

 
 

C

0.11

 

0.35

 

0.12

 

 

T

           

Rs11066323

AA

0.027 (0.081)

4.61(1.1; 19.37)

0.84

1.17 (0.21; 6.54)

0.19

2.33 (0.64; 8.46)

 

AG

0.69

 

0.85

 

0.73

 
 

GG

0.58

 

0.92

 

0.83

 
 

A

0.19

 

0.97

 

0.5

 
 

G

           

TNFα

 

 

 

 

 

 

 

Rs1800629

AA

0.75

 

0.35

 

0.64

 
 

AG

0.13

 

0.2

 

0.09

 
 

GG

0.11

 

0.39

 

0.15

 
 

A

0.14

 

0.67

 

0.27

 

 

G

           

Rs361525

AA

0.038 (0.11)

13.36(1.18;151.24)

-

 

0.21

 

AG

0.238

 

0.74

 

0.39

 
 

GG

0.44

 

0.74

 

0.52

 
 

A

           

 

G

0.71

 

0.75

 

0.67

 

IL23R

 

 

 

 

 

 

 

Rs11805303

TT

0.18

 

0.029 (0.087)

2.50(1.08; 5.81)

0.023 (0.069)

2.37 (1.11; 5.07)

 

TC

0.72

 

0.31

 

0.35

 
 

CC

0.66

 

0.73

 

0.63

 
 

T

           

 

C

0.35

 

0.2

 

0.16

 

PTPN2

 

 

 

 

 

 

 

RS2542151

GG

0.53

 

0.013 (0.039)

6.23(1.18;32.95)

0.038 (0.11)

4.76 (0.94; 24.04)

 

GT

0.44

 

0.16

 

0.15

 
 

TT

0.58

 

0.77

 

0.61

 
 

G

0.73

 

0.51

 

0.76

 

T

 

 

 

 

 

CI: Confidence Interval; OR: Odds Ratio
Significant associations are highlighted in bold. a Two-tailed P values were calculated by home-made program written in R language. b Corrected P values Pcorr — after Bonferroni correction— are shown in brackets.

Table 4: Genotypic and allelic association tests of PTPN11, TNFα, IL23R and PTPN2 SNP polymorphisms with IBD (CD and UC).