GENE/SNP |
Genotype/ |
CD |
UC |
IBD |
Allele |
P valuea (Pcorr)b |
OR (95 % CI) |
P valuea (Pcorr)b |
OR (95 % CI) |
P valuea (Pcorr)b |
OR (95 % CI) |
PTPN11 |
|
|
|
|
|
|
|
Rs11066320 |
AA |
0.69 |
|
0.6 |
|
0.56 |
|
|
AG |
0.022 (0.066) |
2.48 (1.17; 5.25) |
0.09 |
1.67(0.89;3.15) |
0.019 (0.057) |
1.93(1.11; 3.36) |
|
GG |
0.018 (0.054) |
0.4 (0.19; 0.82) |
0.06 |
0.58 (0.32; 1.06) |
0.011 (0.033) |
0.51 (0.3; 0.86) |
|
A |
0.034 (0.068) |
1.90(1.08; 3.33) |
0.079 |
1.50(0.93; 2.42) |
0.02 (0.04) |
1.64 (1.08; 2.49) |
|
G |
|
|
|
|
|
|
Rs12423190 |
CC |
0.48 |
|
0.35 |
|
0.24 |
|
|
CT |
0.16 |
|
0.54 |
|
0.23 |
|
|
TT |
0.12 |
|
0.42 |
|
0.15 |
|
|
C |
0.11 |
|
0.35 |
|
0.12 |
|
|
T |
|
|
|
|
|
|
Rs11066323 |
AA |
0.027 (0.081) |
4.61(1.1; 19.37) |
0.84 |
1.17 (0.21; 6.54) |
0.19 |
2.33 (0.64; 8.46) |
|
AG |
0.69 |
|
0.85 |
|
0.73 |
|
|
GG |
0.58 |
|
0.92 |
|
0.83 |
|
|
A |
0.19 |
|
0.97 |
|
0.5 |
|
|
G |
|
|
|
|
|
|
TNFα |
|
|
|
|
|
|
|
Rs1800629 |
AA |
0.75 |
|
0.35 |
|
0.64 |
|
|
AG |
0.13 |
|
0.2 |
|
0.09 |
|
|
GG |
0.11 |
|
0.39 |
|
0.15 |
|
|
A |
0.14 |
|
0.67 |
|
0.27 |
|
|
G |
|
|
|
|
|
|
Rs361525 |
AA |
0.038 (0.11) |
13.36(1.18;151.24) |
- |
|
0.21 |
|
|
AG |
0.238 |
|
0.74 |
|
0.39 |
|
|
GG |
0.44 |
|
0.74 |
|
0.52 |
|
|
A |
|
|
|
|
|
|
|
G |
0.71 |
|
0.75 |
|
0.67 |
|
IL23R |
|
|
|
|
|
|
|
Rs11805303 |
TT |
0.18 |
|
0.029 (0.087) |
2.50(1.08; 5.81) |
0.023 (0.069) |
2.37 (1.11; 5.07) |
|
TC |
0.72 |
|
0.31 |
|
0.35 |
|
|
CC |
0.66 |
|
0.73 |
|
0.63 |
|
|
T |
|
|
|
|
|
|
|
C |
0.35 |
|
0.2 |
|
0.16 |
|
PTPN2 |
|
|
|
|
|
|
|
RS2542151 |
GG |
0.53 |
|
0.013 (0.039) |
6.23(1.18;32.95) |
0.038 (0.11) |
4.76 (0.94; 24.04) |
|
GT |
0.44 |
|
0.16 |
|
0.15 |
|
|
TT |
0.58 |
|
0.77 |
|
0.61 |
|
|
G |
0.73 |
|
0.51 |
|
0.76 |
|
|
T |
|
|
|
|
|
|
CI: Confidence Interval; OR: Odds Ratio
Significant associations are highlighted in bold. a Two-tailed P values were calculated by home-made program written in R language. b Corrected P values Pcorr — after
Bonferroni correction— are shown in brackets.
|