Organ-Specific Autoimmune Diseases
Organ Disease(s) Self-Antigen Major Autoimmune Mechanism
Adrenal cells Addison's disease Cytochrome P-450 antigens Autoantibodies
Red blood cells Autoimmune hemolytic anemia Red blood cell membrane proteins Autoantibodies
Platelets Idiopathic thrombocytopenic purpura Platelet antigens (GP IIb/IIIa) Autoantibodies
Stomach Pernicious anemia Gastric parietal cell antigens (H+/ATPase, intrinsic factor) Autoantibodies/T cells
Small bowel Celiac sprue (gluten enteropathy) Transglutaminase Autoantibodies/T cells
  Thyroid Hashimoto's thyroiditis Thyroid cell antigens (e.g., thyroglobulin) T cells/autoantibodies
Graves' disease Thyroid-stimulating hormone receptor Autoantibodies
Muscle Myasthenia gravis Acetylcholine receptors Autoantibodies
Pancreatic islets               Type 1 diabetes Beta cell antigens (glutamic acid decarboxylase, insulin) T cells (autoantibodies present
Hepatocytes Autoimmune hepatitis Hepatocyte antigens (cytochrome P450 2D6) T cells/antibodies
Bile duct cells                   Primary biliary cirrhosis Intrahepatic bile duct (pyruvate dehydrogenase complex protein) Autoantibodies/ T cells
Heart           Rheumatic heart disease Myocardial antigens Autoantibodies
Kidney/lung Goodpasture's syndrome Basement membrane antigens (type IV collagen α3 chain) Autoantibodies
Systemic Autoimmune Diseases
Disease(s) Self-Antigen Major Autoimmune Mechanism
Ankylosing sponkylitis Vertebrae Immune complexes
Multiple sclerosis Brain or white matter TH1 cells and TC cells, auto-antibodies
Rheumatoid arthritis Connective tissue, IgG Auto-antibodies, immune complexes
Systemic lupus erythematosus  DNA, nuclear protein, RBC and platelet membranes Auto-antibodies, immune complexes
Scleroderma Nuclei, heart, lungs, gastrointestinal tract, kidney Auto-antibodies
Sjogren’s syndrome Salivary gland, liver, kidney, thyroid Auto-antibodies
Table 1: Examples of selected human autoimmune diseases.