Autoimmune Diseases HLA Molecule Strength of Association
Ankylosing spondylitis HLA-B27 (Caucasians) ++++
Rheumatoid arthritis HLA-DR4
HLA-DRB1*04
+++
Systemic lupus erythematosus HLA-DR2, DR3 ++
Sjögren's syndrome HLA-DR3 ++
Psoriatic spondylitis HLA-B27 +++
Dermatitis herpetiformis HLA-DR3 +++
Gluten-sensitive enteropathy (celiac disease) HLA-DQ2 +++
Type 1 diabetes mellitus HLA-DR3, DR4, DQ2, DQ8 +++
Hyperthyroidism (Graves') HLA-DR3, B8 +
Hashimoto’s Thyroiditis HLA-DR3, DR5 ++
Adrenal insufficiency HLA-DR3 ++
Myasthenia gravis HLA-B8, HLA-DR3 +
Multiple sclerosis HLA-DR2 ++
Table 2: HLA alleles associated with selected human AD.