Mouse

Human

FcγR

FcγRI

FcγRIIRB

FcγRIII

FcγRIV

FcγRIA

FcγRIIA

FcγRIIB

FcγRIIC

FcγRIII A

FcγRIIIB

Signalling pathways

ITAM FcR-γ

ITAM

ITAM FcR-γ

ITAM FcR-γ

ITAM FcR-γ

ITAM

ITAM

ITAM

ITAM FcR-γ

 

affinity

High

Low

Low

Low

High

Low

Low

Low

Low

Low

monocytes/macrophages

+

+

+

+

+

+

+

+

Neutrophils

+

+

+

+

+

+

+

+

Dentritic cells

+

+

+

+

+

+

+

B cells

+

+

Mast cells

+

+

Table 1: Comparison of FcγR between humans and mice.