Diseases

Model

Type NKT cells

Implicated Mechanism

References

Diabetes

NOD

I

IL-4, IL-10 production

Inhibition development pathogenic T cells

Selective recruitment of tolerogenic DC

[44,100]

[40]

[43]

Multiple sclerosis

EAE

I

IL-4, IL-10 production

Reduced INF-γ production

[26,101,102]

[48,101-103]

Myasthenia gravis

EAMG

I

Reduced INF-γ  
Reduced Acetylcholine-specific antibody
CD4+, CD25+ regulatory T cells

[62]

[63]

Rheumatoid arthritis

CIA

CD1d- and Jα18-knockout mice

I

I

Induction of IL-4 and IL-10 expression
Production of IL-4 and IFN- γ

[75,76,78,104]

Allergic Asthma

OVA challenged Jα18-/- mice
Mice treated with
DPPE-PEG

I

I

IL-13, IL-4 production;

Production of IFN-γ;
Production of IL-4

[68]

[70,105]

Table 1: Roles of NKT cells in autoimmune disorders and asthma.