Marker category Gene symbols
Non-HLA genes with risk SNPs [2] BACH 2 GALC MPHOSPH9 SP1 40
BATF HHEX MPV17L2 STAT3
CBLB IL12B MYB TAGAP
CD6 IL22RA2 MYC THEMIS
CLECL1 IL2RA NFKB 1 TMEM 39A
CLECL16A IRF8 NRM TNFRSF6B
CXCR5 KIF2IB OLIG3 TNFSF14
CYP24A1 KPNB1/TBKBP1/TBX21 PLEK TNP2
CYP27B1 MALT1 PTGER 4 TYK2
DKKL1 MAPK1 PVT1 VCAM 1
EOMES MERTK RGS 1 X
EPS15L1 MLANA RPS6KB1 ZFP36L1
EVI 5 MMEL 1 SCO2 ZNF767
HLA risk alleles [1-3] HLA C*05 HLA DRB*14 HLA DRB1*07 HLA DRB1*15:01
HLA DRA*02 HLA DRB1*01:08 HLA DRB1*13:01 HLA DRB5
HLA DRB*12 HLA DRB1*04:05 HLA DRB1*13:03 HLA G
Genes with with protective SNPs or Alleles [1,2,7,8] HLA B*44+HLA DRB1*1501 absent
HLA A*02      
NOTCH4      
Diagnostic marker on gene, RNA and/or cell level in PBMCs [1,2,4-8,36] ANXA (+) NPEPPS (+) CD58 (+) CDK4 (-)
C7orf54 (+) TRIB2 (+) CD40 (+) GNG2 (-)
CXCR4 (+) IL7R (+) ZMIZ1 (-) PAK2 (-)
ITPR1 (+) TNFAIP3 (+) TNFRSF1A (-) TGFBR2 (-)
Genetic marker associated with treatment response
[1,2,5-8,36,68,88]
CTSS (IFN b) LMP7 (IFN b) MxA (IFN b) HLA DRB1*04:08 (IFN b)
IFNAR1 (IFN b) IL7 (IFN b) MBP (GA) HLA DRB1*04:01 (IFN b)
FAS (GA) IL12RB2 (GA) IL1R1 (GA)  
(+)=upregulated mRNA levels and (-)=downregulated mRNA levels in PBMC from MS patients; Genes with SNPs associated with treatment response to GA are marked (GA) and to IFN beta are marked (IFN b)
Table 1: Selection of indicative factors on gene level.