Figure 1: Structure of the human PKCθ protein.
Individual domains in the PKCθ regulatory and catalytic regions are indicated by rectangles with different colors. Molecules that bind PKCθ and are mentioned in the text are indicated above the enzyme (in light blue rectangles) and arrows point to specific PKCθ domains that mediate these interactions. PICOT is a representative of a growing number of proteins that were found to physically interact with PKCθ. Black lines represent phosphorylation sites and the type of amino acid residue that undergoes phosphorylation and its position is indicated below the black line. Kinases that are known to phosphorylate specific amino acids on PKCθ are indicated in a green box below the relevant phosphosite.
V: Variable domain; C: Constant domain; PTB: Phosphotyrosine Binding module; PS: Pseudosubstrate region; PR: Proline-Rich motif; SB: Substrate Binding region; DAG: Diacylglycerol; GLK: Germinal center kinase (GSK)-like kinase; PICOT: PKC-Interacting Cosine of Thioredoxin; Lck: Lymphoid cell kinase.