Mouse Models

Common features

Unique features

References

itk-/-; itk-/-rlk-/-
cbp-/-; klf2-/-
β-catenin-/-

CD8αβ+
TCRαβ+
CD44hi
Ly6c+
CD122+
CXCR3+
Eomes+
Rapid TCR mediated IFN-γ production

Altered disease susceptibility*
Reduced CD5 expression*
IL-15 dependent*
Selected by MHC class Ia or Ib on haematopoietic cells
Development of memory-like T cells is SAP dependent*
Elevated IL-4 producing PLZF+ cell population

[164]

[165,166]
[167,168]
[67,72,169]

[170]

[66]

id3-/-

Selection by TECs
Development of memory-like T cells is SAP-dependent
Elevated CD5 expression
Susceptible to Sjogren’s disease
Elevated IL-4 producing PLZF+ cell population

[69]

 

[171,172]
[69]

nfκb1-/-

IL-15 independent
No evidence of an elevated PLZF+ cell population
Selected by MHC class Ia or Ib on haematopoietic cells
Elevated CD5 expression
Reduced intrathymic Sirpαhi DCs

[57]

Balb/c

KLF13 dependent
Altered disease susceptibility
Wild-type mouse strain

[74]
[75,76]

* Denotes features to be confirmed in CBP, KLF2 and β-Catenin deficient mice.
Table 1: Distinguishing features of memory-like CD8+ T cells in wild-type and mutant mouse models.