PRR Coccidioidal component Effect References
TLR2
TLR4
Dectin-1
MR
SP-A
SP-D
Unidentified
Unidentified
b-glucans
Mannan
Unidentified
Unidentified
Low TNF-a, MIP-2 and IL-6 levels
Low fungal burden in spleen
High TNF-a, MIP-2, IL-12 and IL-6 levels
Spherule binding to DC
uptake/phagocytosis ?
uptake/phagocytosis ?
[41]
[42]
[41,51]
[33]
[60]
[60]
PRR: Pattern Recognition Receptors; PAMP: Pathogen-Associated Molecular Patterns; TLR: Toll-like Receptor; MR: Mannose Receptor; SP: Surfactant Protein; DC: Dendritic Cell
Table 1: Interaction between PRRs and coccidioidal PAMP components, and its effect.