Figure 4: Gene Organization and Major Structural Classes of Cathelicidins
Cathelicidins are ancient gene-encoded (four exons) immune compounds produced in the bone marrow as pre-pro-peptides with a conserved signal- and cathelin- domain, stored as pro-peptides in neutrophil granules, prior to extracellular release and cleavage into mature (variable) cathelicidin HDPs. AA: amino acid. The cathelicidins listed here are human (LL37), and porcine (PR39, Protegrin-3). Figure content also based on: Scand. J. Infect. Dis. 35: 670-6, 2003.