| Study |
Healthy subjects (n) |
Gingivitis subjects (n) |
Mild perio subjects (n) |
Moderate perio subjects (n) |
Chronic perio subjects (n) |
Generalized aggressive severe subjects (n) |
Chronic with immunosuppressant subjects (n) |
Conclusion |
| Bostanci et al., (GCF) [68] |
21 |
22 |
|
|
28 |
25 |
11 |
GCF RANKL &OPG were oppositely regulated in periodontitis groups. |
| Bostanci et al., Gingival tissue [69] |
9 |
8 |
|
|
11 |
12 |
10 |
RANKL/OPG ratio increased in all periodontitis groups. |
| Lu et al. (GCF and gingiva) [6] |
4 |
|
|
|
20 |
|
|
GCF RANKL, but not OPG was elevated in periodontitis groups. |
| Mogi et al., (GCF) [70] |
28 |
|
27 |
58 |
|
47 |
|
RANKL/OPG ratio was significantly elevated in periodontitis groups. |
| Liu et al., (Gingival tissue) [71] |
6 |
|
|
27 |
|
25 |
|
RANKL/OPG was elevated in
periodontitis groups. |
| Kawai et al., (gingiva and blood) [72] |
12 |
|
|
|
32 |
|
|
sRANKL, but not OPG was significantly higher in periodontitis gropus. |
| Wara-aswapati et al., (gingiva and plaque) [73] |
15 |
|
|
|
15 |
|
|
RANKL/OPG ratio was significantly higher in perioidontitis groups |
| Garlet et al., (gingival tissue) [74] |
10 |
7 |
|
|
20 |
16 |
|
RANKL/OPG and MMP/TIMP expression determined disease progression/severity |
| Nagasawa et al., (gingival tissue) [75] |
2 |
|
|
|
30 |
|
|
OPG is induced by LPS-stimulated gingival fibroblast. |
sRANKL: Soluble Receptor Activator of Nuclear Factor-Kappa B Ligand; TIMP: Tissue Inhibitors of Metalloproteinases; LPS: Lipopolysaccharides; perio: Periodontitis