Signaling Molecule Involved in Regulating Reference #
     
miR-146a AICD [69]
miR-29 Helper T cell differentiation [69]
miR-155, miR-221 T cell activation [71,72]
miR-K12-3, miR-K12-7 IL-6 and IL-10 production [52]
PD-1 T cell exhaustion [10, 12, 13]
Blimp-1 T cell exhaustion [19]
CTLA-4,2B4, CD160, GP49B T cell exhaustion [10, 22-26]
LAG-3 T cell exhaustion [10, 22-26]
IRF-3 and Bax T cell apoptosis [41, 42]
NS1 protein host immune system [44]
NS3/4 A host immune system [45]
V protein T cell apoptosis [46]
ISG56 IFN1 production [47]
3Cpro cystein protease IFN1 production [48]
TAR miRNA host ERCC1 and IER3 [51]
CPAF Bik, Puma and Bim degradation [54]
TRAF3 T cell activation [57]
NF-κB, bcl-2 T cell apoptosis [58]
NF-κB, cytochrome c T cell apoptosis [59]
B7-H1 apoptosis of tumor-reactive T cells [16]
Tim-3 immunosuppression, T cell
exhaustion
[60, 10, 25]
Galectin-1 T cell apoptosis [61]
TRAIL-R1 host immune system [62]
Fas host immune system [63]
STAT-3 immunosurveillance [65, 66, 67]
IDO immunosurveillance [68]
Fas-FasL T cell apoptosis [74]
XIAP apoptosis [78,79, 82]
Bcl-2, Bcl-XL, Bcl-W apoptosis [83]

Table 1: Signaling Molecules and their role in T cell Regulation