Figure 3: Schematic diagram depicting ligand-targeted accumulation of Ganoderic Acid-Infused Nanoparticles (GAIN) with both diagnostic and therapeutic functions. Both GA-A and imaging-dye are conjugated to a biocompatible polymer that bonded to a folate ligand to trigger internalization. GAIN preferentially target the folate receptor-rich cancer cells, where linkages are hydrolyzed and the nanoparticles release the drug and dye, allowing drug delivery as well as imaging of tumor tissue.