Target |
Target Cell |
Intervention |
Main
Result(s) |
Reference |
PLK-1 |
RA
synoviocytes |
Si-PKL-1 |
↓ PKL-1
↓ proliferation in response to
IL1β |
143 |
NF-κB |
RA-FLS |
Si-NF-κB (p65
or p50) ±
REL10961 |
↑ Apoptosis |
144 |
GADD45β |
RASF |
Si-GADD45β2 |
↑ Apoptosis
↓ bcl-2, ↑ bax |
145 |
CDK-2,MCP-1 |
RASF |
miR-124a3 |
↓proliferation
G1 phase
arrest |
146 |
Fas-associated
factor-1 |
Jurkat T-
cells |
miR-146a4 |
↓ Apoptosis |
147 |
1REL1096 is the p65 (Rel A) subunit of NF-κB
2 GADD45β is the growth arrest and DNA-damage-inducible45β protein [148]
3Putative consensus sites for the binding of miR-124a and miR-146a to the 3’-untranslated regions of cyclin-dependent kinase-2 (CDK-2) and MCP-1, respectively
4Putative consensus site for the binding of miR-146a to the 3’ untranslated region of Fas-associated factor-1 |