Target

 Target Cell

Intervention

    Main 
   Result(s)

 Reference

     PLK-1

        RA  
 synoviocytes

    Si-PKL-1

   ↓ PKL-1
↓ proliferation in response to
      IL1β

     143

     NF-κB

    RA-FLS

  Si-NF-κB (p65
    or p50) ±
    REL10961

Apoptosis

     144

  GADD45β2

     RASF

  Si-GADD45β

↑ Apoptosis
↓ bcl-2, ↑ bax

     145

CDK-2,MCP-1

    RASF

   miR-124a3

↓proliferation
  G1 phase
    arrest

     146

 Fas-associated
    factor-1

   Jurkat T-
      cells

   miR-146a4

Apoptosis

     147

1REL1096 is the p65 (Rel A) subunit of NF-κB
2 GADD45β is the growth arrest and DNA-damage-inducible45β protein [148]
3Putative consensus sites for the binding of miR-124a and miR-146a to the 3’-untranslated regions of cyclin-dependent kinase-2 (CDK-2) and MCP-1, respectively
4Putative consensus site for the binding of miR-146a to the 3’ untranslated region of   Fas-associated factor-1

Table 2: Use of Silencing RNA or microRNA (miR) Technology to Probe Potential Targets for Inducing Apoptosis in RA Synovium or T-cells