HI AVINA CD4+ T cell Proliferation IFN-γ (pg/ml) IL-5 (pg/ml)
H1N1 pre post Responsea pre post Responseb pre post Responsec pre post Responsed pre post Responsed
LAIV-1 5 20 R 52 199 R 1.9 7.5 4.0 82 64 0.8 59 49 0.8
LAIV-2 20 20 NR 295 473 R 2.1 4.4 2.1 106 261 2.5 48 23 0.5
LAIV-3 80 160 NR 60 140 R 5.4 9.6 1.8 78 168 2.1 10 32 3.2
 
TIV-1 160 160 NR 215 623 R 4.8 7.5 1.6 204 178 0.9 14 15 1.1
TIV-2 40 80 NR 494 494 R 3.4 6.8 2.0 812 650 0.8 7 9 1.3
TIV-3 80 160 NR 251 251 R 1.7 2.1 1.2 369 348 0.9 11 164 14.4
 
H3N2  
LAIV-1 80 80 NR 52 199 R 1.4 7.5 5.5 26 40 1.5 20 36 1.8
LAIV-2 <10 20 R 98 134 R 2.4 7.8 3.2 28 74 2.6 25 28 1.1
LAIV-3 40 160 R 55 240 R 2.1 16.1 7.6 31 237 7.7 9 8 0.9
 
TIV-1 20 160 R 148 672 R 1.2 5.5 4.5 19 28 1.5 8 9 1.2
TIV-2 320 320 NR 193 195 NR 4.0 16.2 4.1 1006 6927 6.9 16 33 2.0
TIV-3 20 20 NR 28 61 R 6.5 14.3 2.2 1361 1217 0.9 14 8 0.6
aResponse is a 4-fold or greater increase in titer after vaccination. R denotes Responder; NR denotes Non-Responder.
bResponse is a statistically significant increase in the titer determined by non-linear regression analysis
cResponse is the proliferative index i.e. ratio of T cell proliferation after vaccination, to proliferation measured before vaccination dResponse is the ratio of cytokine concentration measured in supernatants before and after vaccination
Table 4: Examples of antibody and T cell responses to H1N1 and H3N2 antigens after vaccination with LAIV and TIV