Figure 1: Box and whiskers plots (median and range) and 6 month levels of IgM, IgA and IgG respectively in patients with RA receiving either a 6 month fixed retreatment (A), (B), (C) or a non-fixed retreatment protocol (D), (E), (F,). P values shown were calculated using Wilcoxon matched pairs test for non-parametrically distributed data comparing patients before the first cycle of RTX with those remaining in the study 6 months after 4th cycle.