(Median, p25-p75

HGUGM cohort Fixed 6 months retreatment

UCL cohort Non fixed retreatment

Age (years)

57 (35-68)

53 (32-75)

Disease duration (years)

12 (2-20)

21 (8-35)*

Previous DMARDs

3 (1-3)

3 (1-5)

Previous anti-TNF

1.5 (1-2)

1.5 (1-3)

Baseline DAS28

5.3 (2.8-7.0)

6.0 (5.2-8)

Baseline IgG (g/L)

10.1 (8.8-13.2)

12.5 (10.2-15.5)

Baseline IgM (g/L)

1.1 (0.8-1.9)

1.4 (0.8-18)

Baseline IgA (g/L)

2.6 (1.8-3.8)

3.3 (2.5-4.3)