Figure 1

Figure 1: Multiple MRI measures correlate with CD4⁺ counts and/or CD4/CD8 ratio with P-values <0.05 confidence in a SIV-infected macaque study (Li et al. 2011). (a) brain atrophy index bifrontal ratio (BFR) correlates with CD4⁺ T cell counts (R²=0.20); (b) Fractional Anisotropy (FA) of whole brain correlates with CD4⁺ T cell counts (R²=0.21); (c) FA of splenium correlates with CD4⁺ counts (R²=0.22); (d) FA in frontal white matter and genu correlates with CD4/CD8 ratio (R²=0.17 and 0.18); (e) Cerebral Blood Flow (CBF) in caudate, parietal and prefrontal cortex correlates with CD4⁺ counts (R²=0.21, 0.29, and 0.25) (f) CBF in caudate and parietal cortex correlates with CD4/CD8 ratio(R²=0.21 and 0.50).