Group

Dose
of radiation

Transplanted cells

Dose of antibodies

G1

3 Gy

2×105 Lin−/Sca-1+/c-kit−+10×106 of unfractionated bone marrow

Anti-CD8 0.5 mg i.p. (Day−2)
Anti-CD40L 2×0.5 mg i.p. (Day 0 and Day 4)

G2

3 Gy

2×105 Lin−/Sca-1+/c-kit++10×106 of unfractionated bone marrow

Anti-CD8 0.5 mg i.p. (Day−2)
Anti-CD40L 2×0.5 mg i.p. (Day 0 and Day 4)

G3

3 Gy

2×105 Lin−/Sca-1-/c-kit++10×106 of unfractionated bone marrow

Anti-CD8 0.5 mg i.p. (Day −2)
Anti-CD40L 2×0.5 mg i.p. (Day 0 and Day 4)

C

(−)

(−)

(−)

CP

3 Gy

(−)

Anti-CD8 0.5 mg i.p. (Day −2)
Anti-CD40L 2×0.5 mg i.p. (Day 0 and Day 4)

Table 1: The mixed chimerism induction protocols.