Inducer IFN-γ IFN-α TFN-α IL-12 IL-18 None < 0.06 < 3.1 < 0.13 < 2.1 < 9.2 HSV-2 < 0.08 < 3.6 < 0.12 < 2.2 < 8.9 γ-PGA-APA 400 μg/ml 142 ± 1.8* 186 ± 9.4* 1478 ± 71.0* 919 ± 84.0* 57 ± 6.9* γ-PGA-APA 400 μg/ml + HSV-2 102 ± 2.8° 106 ± 5.4° 980 ± 89.0° 481 ± 52.2° 37 ± 5.9° *Significantly different (p< 0.05) compared with untreated control. °Significantly different (p< 0.05) compared with γ-PGA-APA treated PBMC.

Table 3: Production of Th1 cytokines (pg/ml) at 48 h post γ-PGA-APA treatment by PBMC and under the effect of HSV-2 infection (in grey).Values are the mean of four experiments ± SD.