| Markers |
Expression |
Cutoff value |
Five-year Overall survival (%) |
P (log rank) |
Ten-year Overall survival (%) |
P (log rank) |
Rb |
Downregulation
Overexpression |
> 54.4 |
64.7
47.5 |
0.057 |
54.9
33.2 |
0.027 |
Cyclin D1 |
Downregulation
Overexpression |
> 37.7 |
66.3
48.1 |
0.049 |
58.1
35.6 |
0.023 |
Cyclin B1 |
Downregulation
Overexpression |
£8.6 |
53.3
61.7 |
0.296 |
40.0
53.0 |
0.202 |
Cyclin A |
Downregulation
Overexpression |
> 3.4 |
69.6
49.7 |
0.047 |
54.8
38.3 |
0.041 |
Ki-67 |
Downregulation
Overexpression |
> 28.1 |
71.3
46.5 |
0.010 |
54.5
40.0 |
0.045 |
Topo 2A |
Downregulation
Overexpression |
> 34.2 |
64.5
43.4 |
0.026 |
51.8
37.2 |
0.081 |
p21 |
Downregulation
Overexpression |
£18.4 |
48.0
77.1 |
0.013 |
39.1
69.0 |
0.013 |
p53 |
Dowregulation
Overexpression |
> 77.2 |
60.6
47.8 |
0.203 |
46.6
47.8 |
0.592 |
p27 |
Downregulation
Overexpression |
£8.6 |
31.3
61.0 |
0.002 |
23.4
50.5 |
0.004 |
p16 |
Downregulation
Overexpression |
£41.3 |
51.2
64.8 |
0.137 |
40.0
55.5 |
0.121 |
