Variable

Category

n

HR

95% CI
(HR)

P value

Lymph node metastasis

No

43

1.0

Reference

-

 

Yes

52

4.2

2.1 – 8.3

< 0.001

Cyclin A

Downregulation

32

1.0

Reference

-

 

Overexpression (> 3.4)

63

2.3

1.2 – 4.4

0.017

p 21

Downregulation

70

2.4

1.1 – 5.3

0.037

 

Overexpression (> 18.4)

25

1.0

Reference

-

p 27

Downregulation

13

2.8

1.3 – 5.8

0.007

 

Overexpression (> 8.6)

82

1.0

Reference

-

Treatment

Surgery

35

1.0

Reference

-

 

Surgery + radiotherapy

60

0.8

0.4 – 1.6

0.541

Age

(continuos variable)

95

0.99

0.96 – 1.02

0.544

Table 5: Risk factors for death according to Cox model (final model adjusted for treatment and age).