Figure 2: Unadjusted Kaplan-Meier Curves by HIF-1α staining intensity. Patients with high levels of HIF-1a staining (above median: solid line) in peripheral tumor show significantly worse overall survival (A) and recurrence free survival (C). By contrast, staining intensity of central tumor for HIF-1a shows no association with overall survival (B) or recurrence free survival (D).