| Marker |
Tumor Location |
Stain Intensity |
RFS |
OS |
| |
|
Median |
HR* (95% CI+) |
p |
HR (95% CI) |
p |
| HIF-1α |
Central |
1 |
0.73 (0.22-2.41) |
0.60 |
0.67 (0.22-2.08) |
0.49 |
| |
Peripheral |
1 |
6.65 (1.14-38.97) |
0.04 |
8.65 (1.78-42.06) |
<0.01 |
| |
All Tumor |
1 |
0.92 (0.29-2.89) |
0.89 |
1.01 (0.35-2.96) |
0.98 |
| PDK-1 |
Central |
1 |
0.63 (0.20-2.02) |
0.44 |
0.77 (0.26-2.33) |
0.65 |
| |
Peripheral |
1 |
4.03 (0.65-24.93) |
0.13 |
3.24 (0.84-12.46) |
0.09 |
| |
All Tumor |
1 |
1.89 (0.59-5.99) |
0.28 |
1.62 (0.54-4.82) |
0.38 |
| mTOR |
Central |
0.5 |
0.20 (0.05-0.88) |
0.03 |
0.23 (0.06-0.87) |
0.03 |
| |
Peripheral |
0.67 |
1.38 (0.25-7.54) |
0.71 |
0.70 (0.16-3.11) |
0.63 |
| |
All Tumor |
0.5 |
0.10 (0.01-0.66) |
0.01 |
0.12 (0.02-0.64) |
0.01 |
| pAMPK |
Central |
0 |
0.21 (0.05-0.86) |
0.03 |
0.48 (0.15-1.56) |
0.22 |
| |
Peripheral |
0.17 |
0.54 (0.15-1.93) |
0.34 |
1.78 (0.62-5.09) |
0.28 |
| |
All Tumor |
0.25 |
0.27 (0.08-0.90) |
0.03 |
0.68 (0.24-1.95) |
0.47 |
*Hazard ratio with 95% +Confidence Interval |
