Marker Tumor Location Stain Intensity RFS OS
    Median HR* (95% CI+) p HR (95% CI) p
HIF-1α Central 1 0.73 (0.22-2.41) 0.60 0.67 (0.22-2.08) 0.49
  Peripheral 1 6.65 (1.14-38.97) 0.04 8.65 (1.78-42.06) <0.01
  All Tumor 1 0.92 (0.29-2.89) 0.89 1.01 (0.35-2.96) 0.98
PDK-1 Central 1 0.63 (0.20-2.02) 0.44 0.77 (0.26-2.33) 0.65
  Peripheral 1 4.03 (0.65-24.93) 0.13 3.24 (0.84-12.46) 0.09
  All Tumor 1 1.89 (0.59-5.99) 0.28 1.62 (0.54-4.82) 0.38
mTOR Central 0.5 0.20 (0.05-0.88) 0.03 0.23 (0.06-0.87) 0.03
  Peripheral 0.67 1.38 (0.25-7.54) 0.71 0.70 (0.16-3.11) 0.63
  All Tumor 0.5 0.10 (0.01-0.66) 0.01 0.12 (0.02-0.64) 0.01
pAMPK Central 0 0.21 (0.05-0.86) 0.03 0.48 (0.15-1.56) 0.22
  Peripheral 0.17 0.54 (0.15-1.93) 0.34 1.78 (0.62-5.09) 0.28
  All Tumor 0.25 0.27 (0.08-0.90) 0.03 0.68 (0.24-1.95) 0.47
*Hazard ratio with 95% +Confidence Interval
Table 3: Multivariate impact of high (above median stain score) metabolic marker staining intensity on overall survival (OS) and recurrence free survival (RFS).